AIP MUTATION DATABASE

The AIP mutation database collects variants (both pathogenic, non-pathogenic and with unknown significance) related to pituitary adenoma predisposition (PAP) and to familial isolated pituitary adenoma (FIPA) syndromes and their clinical information in order to understand better the molecular and clinical details of the disease. We invite everyone interested to search the available information. We also strongly encourage users to submit new variants and/or new clinical data, thereby contributing to develop this extremely valuable tool. In order to submit new information a free registration is required.



Available datasets:



Sequences
AIP reference sequences
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AIP in other organisms
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Additional information
About the database
Bioinformatics tools
In this section we provide a list of useful bioinformatic tools, which can assist users to assign the correct name and to estimate in silico the pathogenicity of newly identified variants

- Primer3 for primer design
- Pathogenic-Or-Not-Pipeline (PON-P) for in silico predictions
- Alamut for in silico predictions
- Mutalyzer for mutation nomenclature
- Clustal Omega for sequence alignments
- HapMap for variants frequency data
AIP in other databases
Below we list here other website pages where users can find clinical, molecular, genetic and structural information about AIP

- OMIM
- Orphanet
- UCSC Genome Browser
- Ensembl Genome Browser
- GeneReviews
- GeneCards
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